Vitamin B9, or Folate, is essential for the growth and reproduction of all body cells and is especially important during periods of high growth, such as infancy, adolescence and pregnancy. As almost half of all pregnancies in the United States are unexpected or unplanned (see New England Journal of Medicine article below), women in their childbearing years are routinely encouraged to take a multivitamin containing vitamin B9 to help prevent neural tube defects (NTDs). Folate also plays an important role in reducing the risk of heart disease, and is known to reduce homocysteine levels in our blood. Epidemiologic data also links low levels of folic acid with some cancers.
Sources of Folate
Folate and folic acid are forms of the water-soluble vitamin B9. Folic acid is the synthetic form of vitamin B9, while folate is the form of vitamin B9 found in food. Folate is naturally found in dark leafy vegetables, asparagus, okra, fruits (including bananas, lemons, oranges, and melons), mushrooms, legumes, soybeans, brewer’s yeast and orange and tomato juices. Breads, cereals, bars and flour are commonly fortified with folic acid.
Recommendations
The U.S. Recommended Daily Allowance (RDA) for adults is 500 micrograms (mcg) daily (600 mcg daily for pregnant women), with the tolerable upper intake level (UL) set at 1,000 mcg.
There is concern in the scientific community that large populations within the United States have folic acid levels that are too high. Between fortification of foods and consumption of supplements, researchers estimate that a third of our population has folic acid levels at twice the recommended level. Vitamin B-12 deficiency, fairly common in seniors, can be masked in individuals with excessive folic acid levels.
Cooper Complete
The formulations of all Cooper Complete nutritional supplements are overseen by a team of researchers and physicians, and all of our products are reviewed and adjusted to ensure that the formulations contain levels of ingredients scientifically proven to be beneficial for optimal health. We are in the process of revising all of the Cooper Complete multivitamins (adult formulations) from 400- to 200 mcg of folic acid. During this formulation change, we are also transitioning to Metafolin, a brand name for a patented form of 5-methyltetrahydrofolate (5-MTHF) made by Merck. Metafolin is a form of folate that is more body-ready and usable by the body compared to the typical folic acid that is contained in supplements. 5-MTHF is the predominant form of folate that is found in nature and may have benefits over synthetic folic acid. A percentage of the population has a mutation in one of the enzymes involved in the metabolism of folic acid, and 5-MTHF circumvents this mutation and allows the body to be better able to get the benefits from supplementation. We expect to transition all adult formulations to the new level and form by early next year.
To purchase Cooper Complete multivitamins and supplements, visit the Cooper Store
References
Family Planning as a Cost-Saving Preventive Health Service
Unmetabololized Folic Acid in Plasma is associated with Reduced Natural Killer Cell Cytotoxicity among Postmenopausal Women
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